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The effects of vorinostat on erlotinib-resistance of lung adenocarcinoma cells / 安徽医科大学学报
Acta Universitatis Medicinalis Anhui ; (6): 1500-1503, 2017.
Article in Chinese | WPRIM | ID: wpr-667945
ABSTRACT
Objective To investigate the impact of vorinostat(SAHA) on the erlotinib-resistance of human lung adenocarcinoma cell line PC-9/ER.Methods PC-9/ER cells were treated with erlotinib and SAHA,alone or in combination.The effects of proliferation inhibition were assayed by MTT method,the apoptosis ratios of cells were analyzed by flow cytometry.Results The results showed that SAHA inhibited the proliferation of PC-9/ER cells in a dose-dependent manner alone.The non-toxic doses of SAHA (1 μmol/L) significantly improved the sensitivity of PC-9/ER to Erlotinib,and induce apoptosis.Conclusion SAHA could partially improve PC-9/ER sensitivity to erlotinib.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Acta Universitatis Medicinalis Anhui Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Acta Universitatis Medicinalis Anhui Year: 2017 Type: Article