Clinicopathological analysis of 19 cases with congenital nonprogressive hemangiomas / 临床与实验病理学杂志

ABSTRACT

Purpose To investigate the clinicopathological features and differential diagnosis of congenital nonprogressive hemangiomas in children.Methods The clinic pathologic data and follow-up results of 19 cases of congenital nonprogressive hemangiomas were collected.The histopathologic features of congenital nonprogressive hamangiomas were observed with HE staining and immunohistochemistry of EnVision two-step.Results Of the 19 patients,13 were males and 6 were females,with an average age of 52.4 months and medium age of 48 months.9 cases occurred in the limbs and trunk,10 lesions were located in head and face included 1 case with multifocal lesions.Grossly,the specimens were irregular solid mass with range from 0.4 cm to 7 cm in maximum diameter.Microscopically,the lesions were composed of capillary lobules that separated by abnormal dense fibrotic dermal stroma typically containing a prominent component of large vessels.Immunohistochemically,the tumor cells were positive for CD31,CD34,and WT1,but negative for D2-40 and GLUT1.All eases underwent surgical resection,and the follow-up period was 1-24 months.There was no recurrence or metastasis.Conclusion Congenital nonprogressive hemangioma is a rare benign vascular tumor in children,with characteristic clinical and pathologic features.So the exact diagnosis is very important for both pathologists and clinicians.