Expression of FOXM1 in colorectal carcinoma and its clinical significance / 临床与实验病理学杂志

ABSTRACT

Purpose To investigate the expression of forkhead box M1 (FOXM1) in human colorectal cancer(CRC) tissues,and to analyze the correlation between its expression and clinicopathological parameters and prognosis of CRC.Methods The expression of FOXM1 was examined in 297 cases of CRC tissues and 80 cases of normal peritumoral tissues by immunohistochemistry of SP.Western blot was used to detect the expression of FOXM1 in 20 cases of fresh CRC tissues and the corresponding normal peritumoral tissues.Results The expression of FOXM1 was significantly higher in CRC tissues (60.6％) compared with normal peritumoral tissues (17.50％,P ＜ 0.01).The positive expression of FOXM1 was related to the depth of invasion,lymph node metastasis,intravascular cancer embolus,distant metastasis and TNM stage (P ＜ 0.05).However,there was no correlation with age,sex,tumor location,tumor size,tumor differentiation degree,CEA and CA199 (P ＞0.05).The relative expression levels of FOXM1 protein was also significantly higher in CRC tissues (0.855 ± 0.063) compared with corresponding normal peritumoral tissues (0.150 ± 0.041,P ＜0.01).The 3-year overall survival of CRC patients with FOXM1 expression was significantly lower than that of patients without FOXM1 expression (P＜0.01),and FOXM1 is an independent prognostic factor for CRC.Conclusion The overexpression of FOXM1 protein in CRC tissues correlate with the clinicopathological characteristics and prognosis.FOXM1 may play an important role in the occurrence and metastasis of CRC,and it may be a new tumor marker and potential therapeutic target for CRC.