Compatibility law of Schisandra chinensis prescription of Chinese patent medicine in Chinese pharmacopoeia / 中国药理学通报

ABSTRACT

Aim To summarize the 2015 version of the prescrip-tion preparations containing Schisandra chinensis in "Chinese Pharmacopoeia",and discover meaningful compatibility law of Schisandra chinensis. Methods The statistics of prescription preparations relating to Schisandra chinensis in 2015 edition of "Chinese Pharmacopoeia" were gathered to find the frequency of each herbal medicine,efficacy,medicine category,and dosage. A database was constructed and frequency statistics were coun-ted,the dendrogram was built by cluster analysis to get compati-bility law of herbal medicines,and then some modern research analysis was conducted. Results A total 100 kinds of prescrip-tion preparations were included,including 128 Chinese medi-cines,and the total using frequency was 906 times. A sum of 17 types of traditional Chinese medicine were used in this study, and most commonly used herbals were Qi-invigorating herbs(fre-quency 150,0. 1656),antipyretic(frequency 115,0. 1269), yin-nourishing herbs(frequency 91,0. 1004),Yang-invigorat-ing herbs(frequency 78,0. 8610),Hematinic(frequency 78, 0. 8610)and so on. The herb medicine of using frequency ranking the first 20 was Prepared Radix Rehmanniae(47),Ra-dix Ophiopogonis (39 ), tuckahoe (38 ), Membranous Milkvetch(36),Ural Licorice (35),ginseng (32),angelica (23),salvia miltiorrhiza(23),wolfberry fruit(21),respective-ly;cluster analysis showed that the traditional Chinese medicine with frequency more than 10 times could be divided into five cat-egories,while Radix Rehmanniae was classified as a separate class. Conclusions The main therapeutic theory about Schisan-dra is astringency,replenishing and promoting production of body fluid and tonifying the kidney to relieve mental strain in 2015 edition of "Chinese Pharmacopoeia". The prescription compatibility can be used for rational medicine Schisandra com-patibility,guiding rational administration for Schisandra chinen-sis,in-depth research and development of modern prescription provide reference.