Modulation of retinal information and retinal diseases / 复旦学报（医学版）

ABSTRACT

In this article a general account of the major results in retina research obtained by my team in the past ten years is provided.The basic research of my team is exemplified by the study of neuromodulatory action of melatonin on retinal neurons.This is followed by a brief description of our endeavor in exploring the pathogenesis of glaucoma,focusing on the involvement of Müller cell gliosis and reverse signaling of the ephrin/Eph signaling system in apoptosis of retinal ganglion cells.Finally,our recent studies,concerning roles retinal dopamine (DA) plays in refractive development and form-deprivation myopia (FDM) are presented.Our results strongly suggest that a DA-independent mechanism may work together with a DA-dependent mechanism,mediating refractive development and FDM formation.