Imapct of laparoscopic myomectomy on IL-6, IL-2, and CRP in patients with uterine fibroids / 中国内镜杂志

ABSTRACT

Objective To investigate the effect of laparoscopic myomectomy for uterine fibroids. Methods From February 2015 to February 2016, 84 cases of uterine fibroids were selected, 51 patients underwent laparoscopic myomectomy (observation group), and 33 patients received abdominal myomectomy (control group), the operation time and intraoperative blood loss and so on were observed in two groups, C reactive protein (CRP), interleukin-2 (IL-2), IL-6, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and antral follicle (AFC) were detected before and after operation. Results The operation time of the observation group was (74.29 ± 13.20) min, significantly higher than the control group (P < 0.05), the amount of bleeding, postoperative exhaust time, hospitalization time and intraoperative myoma rejection number were (105.39 ± 32.04) ml, (17.40 ± 2.31) h, (4.02 ± 1.32) d and (6.02 ± 1.32), significantly less than the control group (P < 0.05); The CRP and IL-6 in the observation group were (25.20 ± 5.32) mg/L and (38.04 ± 10.11) ng/ml, significantly lower than those in the control group (P < 0.05), while IL-2 was (46.13 ± 13.10) ng/ml, was significantly higher than that of the control group (P < 0.05); The incidence of postoperative complications in the observation group was 3.92％, which was significantly lower than that in the control group (P < 0.05); There was no significant difference in the levels of (FSH, LH and AFC between the two groups (P > 0.05); The postoperative recurrence rate and pregnancy rate in the observation group were 21.56％ and 54.90％, compared with the control group, there was no significant difference (P > 0.05). Conclusion Laparoscopic myomectomy is safe and effective in treatment of uterine fibroids with less stress response and no effect on ovarian function.