The Expression and Significance of miR-608 in Ameloblastoma / 中国医科大学学报

ABSTRACT

Objective To study the expression and significance of miR-608 in ameloblastoma (AB).Methods Quantitative stem-loop RT-PCR was used to detect the expression of miR-608 in 26 cases of human AB (AB group) and 17 cases of peritumoural tissues (control group).The differences in miR-608 levels between the control group and the AB groups,namely,primary AB and recurrent AB,were evaluated.In addition,miR-608 levels in AB cases with different clinical and pathological characteristics were compared.Results The expression level of miR-608 in the AB group was significantly lower than that in the control group (P ＜ 0.05).Additionally,the relative expression level of miR-608 in the primary AB group was significantly lower than that in the recurrent AB group (P ＜ 0.05).There were no significant differences between the miR-608 expression levels with respet to age,gender,or pathological type (P ＞ 0.05).Conclusions The expression of miR-608 in human AB tissue is significantly decreased,which may be related to the recurrence of the tumor.