Levels of Serum CA125, hs-CRP, and TNF-α in Patients with Chronic Heart Failure, and the Association with Cardiac Function / 中国医科大学学报

ABSTRACT

Objective To detect changes in serum cancer antigen 125 (CA125),tumor necrosis factor-alpha (TNF-α),and high-sensitivity C-reactive protein (hs-CRP) in patients with chronic heart failure (CHF),before and after treatment,and to examine the relationship between CA125 and cardiac function.Methods From June 2015 to December 2016,84 patients with CHF in our hospital were selected as the observation group and 72 healthy persons were selected as the control group.Fasting venous blood CA125,TNF-α,and hs-CRP levels were measured before and after treatment.The cardiac left ventricular ejection fraction (LVEF) was measured in both groups using echocardiography.Results The levels of CA125,TNF-α,and hs-CRP in the contml group were significantly lower than those in the observation group.The LVEF in the control group was significantly higher than in the observation group (P ＜ 0.05).After heart failure treatment,the levels of CA125,TNF-α,and hs-CRP significantly decreased in the observation group,and LVEF showed marked improvement (P ＜ 0.05).Analysis showed that the serum CA 125 level in patients with CHF was positively correlated with TNF-α and hs-CRP levels,and was negatively correlated with LVEF.Conclusion The levels of CA125,TNF-α,and hs-CRP in patients with CHF could have potential for the evaluation of CHF status and treatment results.