Effect of alprostadil on hemorrheological indicators of patients with multiple lacunar infarcts / 中国基层医药

ABSTRACT

Objective To observe the effect of alprostadil on hemorrheological indicators of patients with multiple lacunar infarcts.Methods 146 cases with multiple lacunar infarcts were randomly divided into observation group(76 cases) and control group(70 cases) by using the method of random number table.The two groups were given conventional treatment.In addition to this,the observation group was treated with alprostadil.NIHSS was used to evaluate neurological deficits,MMSE was used to evaluate cognitive function.The indicators of hemorheology and nailfold microcirculation integral were detected,adverse drug reactions of the two groups were observed.Results After treatment,the MMSE scores of the two groups [(24.09 ±3.88)points,(22.41 ±4.06)points] were significantly higher than before treatment,the NIHSS scores [(3.67 ± 1.39) points,(4.35 ± 1.62) points] decreased significantly (t =7.241,21.095,6.017,14.179,all P ＜ 0.05).After treatment,the MMSE score of the observation group was higher than that of the control group(t =2.556,P ＜0.05),the NIHSS score of the observation group was lower than that of the control group (t =2.728,P ＜ 0.05).After treatment,the low blood viscosity,whole blood viscosity,plasma viscosity,erythrocyte sedimentation rate,erythrocyte aggregation index,erythrocyte rigidity index,platelet aggregation rate,fibrinogen of the two groups [(11.80 ± 3.65) mPa/s,(10.90 ± 2.05) mPa/s,(1.90 ± 0.48) mPa/s,(12.64 ± 3.53) mm/h,(5.05 ± 1.28),(5.74 ± 1.20),(56.92 ± 13.49) ％,(2.97 ± 0.55) g/L,(17.37 ± 3.87) mPa/s,(12.86 ±2.64) mPa/s,(2.16 ±0.58) mPa/s,(19.70 ±4.26) mm/h,(6.48 ± 1.79),(6.80 ± 1.73),(62.88 ± 13.74)％,(3.52 ± 0.64)g/L] decreased than before treatment,and erythrocyte deformation index [(0.78 ± 0.15),(0.68 ±0.12)] increased (t =24.497,15.398,16.814,24.146,14.709,8.558,10.940,46.550.11.591,10.895,13.755,13.791,6.971,5.140,4.782,4.592,9.357,all P ＜ 0.05).After treatment,the blood rheology indicators of the observation group improved more significantly than those of the control group (t =8.949,5.032,2.960,10.936,5.585,4.424,4.330,2.643,5.582,all P ＜ 0.05).After treatment,the loop shape,loop pattern,periloop state scores of the two groups [(1.14 ± 0.35) points,(1.64 ± 0.45) points,(2.07 ± 0.29) points,(1.30 ± 0.37) points,(1.85 ± 0.60) points,(2.66 ±0.38) points] decreased significantly than those before treatment (t =5.818,14.220,30.083,3.580,7.715,9.933,all P ＜ 0.05).After treatment,the loop shape,loop pattern,periloop state scores of the observation group were lower than those of the control group (t =2.685,2.404,10.595,all P ＜ 0.05).The incidence rate of adverse reaction of the observation group was 7.89％ (6/76),which of the control group was 7.14％ (5/70),the difference was not statistically significant between the two groups(x2 =0.030,P ＞ 0.05).Conclusion In the treatment of multiple lacunar infarcts,alprostadil can effectively improve hemorrheological and nailfold microcirculation integral indicators,improve the nerve defect and cognitive function of patients,the incidence rate of adverse reaction is low,it has high value in clinical application.