Analysis of the clinical value of sufentanil combined with propofol in the treatment of anesthesia in children / 中国基层医药

ABSTRACT

Objective To explore the clinical value of combined treatment of sufentanil and propofol in children during anesthesia induction.Methods 72 children were selected,and they were randomly divided into three groups by full random allocation method:observation group A,observation group B and control group,24 cases in each group.The observation group A was given intravenous infusion of sufentanil(0.01g · kg-1 · min-1),the observation group B was given intravenous infusion of sufentanil (0.02g · kg-1 · min-1),the control group was given intravenous saline infusion,then given propofol target controlled infusion after 30min.The bispectral index (BIS),propofol effect chamber (EC),OAA/S score and time of induction of anesthesia (LOC) time were recorded in the three groups.Results There was a significant correlation between BIS and propofol EC and OAA/S scores in the three groups,and there was a negative correlation between BIS and propofol EC (r =-0.82,-0.79,-0.88,all P ＜ 0.01).BIS and OAA/S score was positively correlated (r =0.86,0.81,0.89,all P ＜ 0.01).Compared with the control group [(9.11 ± 1.04) min],the LOC time of the observation group A and B [(5.37 ± 0.89) min,(4.49 ± 0.63) min] was significantly shortened (t =13.39,18.61,all P ＜ 0.01).The propofol EC of control group was (2.44 ± 0.5) μg/mL,the propofol EC of the observation group A and B [(1.38 ± 0.35) μg/mL,(1.14 ± 0.27) μg/mL] decreased during anesthesia induction (t =8.40,11.04,all P ＜ 0.01),and the effect of the observation group B was better than that of the observation group A (t =3.95,2.67,all P ＜ 0.05).There was no statistically significant difference in BIS between the observation group A and control group [(70 ± 4) vs.(69 ± 7),t =0.61,P ＞ 0.05].The BIS of observation group B (78 ± 5) was significantly higher than that of the observation group A and control group (t =6.12,5.13,all P ＜ 0.01).Conclusion Sufentanil combined with propofol for anesthesia in children has a synergistic effect,which is beneficial to reduce the amount of propofol EC during anesthesia induction,shorten the time of LOC and enhance the sedative effect of propofol,and it is worthy of further clinical application.