Effect of losartan on obesity related metabolic disorder in obese and hypertensive patients / 中国基层医药

ABSTRACT

Objective To analyze the effects of losartan and amlodipine on leptin,adiponectin and insulin sensitivity in obese hypertensive patients.Methods 126 patients with obesity related hypertension were selected,and they were randomly divided into losartan group and amlodipine group according to the digital table,63 cases in each group.The losartan group were treated with losartan 50mg/time,1 time/d.The amlodipine group was given amlodipine 50mg/time,1 time/d.The two groups were given the corresponding drugs for 16 weeks.The body mass index (BMI),heart rate,systolic blood pressure (SBP),diastolic blood pressure (DBP),leptin,adiponectin,HOMA-IR and norepinephrine(NE) levels were measured before and after treatment in the two groups.Results After treatment,the BMI of the losartan group decreased significantly,the difference was statistically significant (t =6.660,P ＜ 0.05),but there was no significant difference in heart rate (t =0.180,P ＞0.05).After treatment,the BMI of the amlodipine group decreased significantly (t =3.647,P ＜ 0.05),heart rate increased significantly,the difference was statistically significant (t =3.098,P ＜ 0.05).After treatment,the BMI and heart rate in the losartan group were significantly lower than those in the amlodipine group,and the differences between the two groups were statistically significant (t =3.106,3.256,all P ＜0.05).After treatment,the SBP and DBP in the two groups were significantly decreased,the differences were statistically significant (tlosartan group =9.503,13.095;tamlodipine group =10.254,11.776,all P ＜ 0.05),there were no statistically significant differences between the two groups (t =0.975,0.659,all P ＞ 0.05).After treatment,the level of adiponectin in the losartan group was significantly increased,the leptin level and HOMA-IR score decreased significantly,the differences were statistically significant (t =4.462,2.004,5.572,all P ＜ 0.05),there was no significant difference in the level of NE (t =0.481,P ＞ 0.05).After treatment,NE level of the amlodipine group was significantly higher,the difference was statistically significant (t =6.090,P ＜ 0.05),there were no statistically significant differences in the levels of leptin,adiponectin and HOMA-IR score (t =0.126,0.053,0.448,all P ＞ 0.05).Conclusion Losartan and amlodipine can effectively control hypertension,but losartan can effectively regulate the metabolic disorder of obesity related hypertension patients with obesity alone,therefore,losartan alone has more significant effect compared with amlodipine.