Diagnostic value of serum and bile survivin levels in obstructive jaundice / 中国现代普通外科进展
Chinese Journal of Current Advances in General Surgery
;
(4): 615-618, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-668579
ABSTRACT
Objective:
To detect the bile and serum survivin levels in patients with obstructive and to determine whether bile and/or serum survivin be helpful in distinguishing malignant obstructive jaundice (cholangiocarcinoma) from benign obstructive jaundice.Methods:
Bile and serum survivin levels were determined using enzyme-linked immunosorbent assay.Receiver operating characteristic (ROC) curve was used to evaluate the feasibility of bile and/or serum in differentiating malignant obstructive jaundice from benign obstructive jaundice.Results:
Mean bile survivin concentrations were significantly higher in cholangiocarcinoma compared to choledocholithiasis,benign biliary stricture,compressive stenosis and normal controls(P< 0.05,respectively).However,only mean serum survivin concentrations were significantly higher in cholangiocarcinoma than normal controls(P=0.009).For bile survivin,the area under the curve (AUC) was 0.780(P < 0.001),and the optimal cut-off value determined was 772.28 pg/mL,providing a sensitivity of 67.27 % and a specificity of 80.85 %.But the AUC was only 0.600 for serum survivin (P=0.084).Conclusions:
These findings reveal that bile survivin is significantly increased in patients with cholangiocarcinoma,and bile survivin may be a useful indicator in differentiating distinguishing cholangiocarcinoma from benign obstructive jaundice.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
/
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Current Advances in General Surgery
Year:
2017
Type:
Article
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