The association of BDKRB2 gene polymorphism with osteoarthritis risk / 医学研究生学报

ABSTRACT

Bradykinin is a kind of inflammation mediums and plays an important role in the development of inflammation .Bra-dykinin B2 receptor(BDKRB2) mediates most bradykinins-associated inflammation,and widely exists in various tissues, including joint tissue.Recent studies increasingly suggest that BDKRB 2 gene polymorphisms is certainly associated with the onset of osteoarthritis ( OA) .This paper reviews the influence of BDKRB 2 gene polymorphism on the susceptibility , severity and related products expression of OA, which facilitates a better understanding of OA and providing new targets and theoretical basis for the OA treatment.