Research progress of of long chain noncoding RNA in regulating osteogenic differentiation / 医学研究生学报

ABSTRACT

Bone marrow mesenchymal stem cells are the main progenitor cells of osteoblasts , and are regarded as the seed cells for bone repair and regeneration because of their osteogenic differentiation potential .Promoting the osteogenic differentiation and bone formation is feasible to treat osteoporosis .LncRNAs regulate gene expression at the transcriptional and post-transcriptional levels , influence fundamental biological processes including cell differentiation and organ development , and are closely associated with many diseases including osteoporosis .This paper reviews the research of lncRNA in regulating osteogenic differentiation to provide a new tar -get for bone formation and treatment of osteoporosis .