Research on relationship between serum mast cell carboxypetidase levels and bronchial asthma / 中国免疫学杂志

ABSTRACT

Objective:To investigate the role of the mast cell carboxypetidase in the pathogenesis of bronchial asthma through measuring the serum.The mast cell carboxypetidase levels of asthma patients,and further study the relationship between the mast cell carboxypetidase levels and pulmonary function or IgE.Methods: There were person with Moderate and severe persistent asthma were recruited into this study as the case group.The experience of the pulmonary function and immunoglobulin E levels have been complicat-ed.The person were divided into IgE increased group(n=20) and IgE normal group (n=15) according to the IgE level.And there were healthy person were recruited as the matched group.The mast cell carboxypetidase were measured using ELISA.The level of mast cell carboxypetidase were compared among asthma patients and healthy patients.The correlation between the mast cell carboxypetidase and IgE or the lung function.Results:The level of plasma mast cell carboxypetidase in the person with asthma was higher than that in healthy control group(P<0.05).The level of plasma mast cell carboxypetidase of the person in IgE increased group was higher than that in IgE normal group(P<0.05).In addition,there was a significant negative correlation between the serum mast cell carboxypetidase levels and FEV1(%) in the asthma acute phase,but there was no correlation in the stability of asthma(r=-0.42,P=0.044;r=-0.284,P=0.099).Conclusion: The mast cell carboxypetidase leve,as an inflammatory factor,could participates in the airway in-flammatory response of the asthma acute phase.