Hybrid PET/MR analysis of neural mechanism for default mode network / 中国医学影像技术

ABSTRACT

Objective To investigate the relationship between spatial distribution of default mode network and glucose uptake.Methods Nine healthy subjects were scanned with hybrid PET/MR.Resting state MRI (rs-fMRI) and PET data were obtained.Spatial distribution analysis was performed between default mode network and glucose uptake.The relationship between the functional connectivity of default mode network and the distribution of glucose uptake were further analyzed.Results The similar spatial distribution pattern was found between default mode network and glucose uptake.Correlation between functional connectivity and glucose uptake in the default mode network showed that the best correlation coefficient between the values of functional connectivity and relative glucose uptake (rGU) was achieved in the right posterior cingulate cortex (rs =0.833,P＜0.001).Conclusion Hybrid PET/MR is very important to investigate neural mechanism of default mode network.