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Metabonomic analysis of the urine from rat model with abnormal sapra syndrome / 中南大学学报(医学版)
Article in Zh | WPRIM | ID: wpr-669236
Responsible library: WPRO
ABSTRACT
Objective:To investigate the correlation between the change in metabolic components of urine and the abnormal sapra syndrome by using a rat model of abnormal sapra syndrome.Methods:Multiple factors,such as dry environment,dry feed,and chronic electrical stimulation,were used to establish the abnormal sapra syndrome in Wistar rats by Uyghur medicine.The differences in metabolites were detected through the metabonomics method.Results:The urine of rats in abnormal sapra syndrome group showed significant high abundance metabolites as follows:Leucine,isoleucine,and glycoprotein.And that significant low abundance metabolites as follows:Glutamine,creatine,citric acid,and phenylalanine.Conclusion:The urine of rats with the abnormal sapra syndrome displays abnormal energy metabolism.It is likely that the dysfunctional metabolisms of three major nutrients might be the molecular basis for the abnormal sapra syndrome.
Key words
Full text: 1 Index: WPRIM Type of study: Prognostic_studies Language: Zh Journal: Journal of Central South University(Medical Sciences) Year: 2017 Type: Article
Full text: 1 Index: WPRIM Type of study: Prognostic_studies Language: Zh Journal: Journal of Central South University(Medical Sciences) Year: 2017 Type: Article