Clinical significance of the changes of the levels of serum hemoglobin, vascular endothelial growth factor,carcinoembryonic antigen, carbohydrate antigen 19-9 and carbohydrate antigen 125 in patients with gastric cancer before and after chemotherapy / 新乡医学院学报

ABSTRACT

Objective To observe the changes of the levels of serum hemoglobin (HGB),vascular endothelial growth factor (VEGF),carcinoembryonic antigen (CEA),carbohydrate antigen 19-9 (CA19-9) and carbohydrate antigen 125 (CA125) in patients with gastric cancer before and after chemotherapy;and to investigate the correlation between the changes of the levels of the serum indexes and the effect of chemotherapy.Methods A total of 100 patients with gastric cancer were selected from June 2015 to June 2016 in the Central Hospital of Tongchuan Mining Bureau.All patients were treated with the primary chemotherapy regimen with fluorouracil and paclitaxel.The levels of serum HGB,VEGF,CEA,CA19-9 and CA125 were detected before and after one cycle of chemotherapy.The curative effect was evaluated after two cycles of chemotherapy.Results Among the 100 patients after two cycles of chemotherapy,there were 25 cases with partial remission (effective group),37 cases with stable disease(stable disease group) and 38 cases with progressive disease (progressive disease group).There was no significant differences in serum HGB level of the 100 patients before and after chemotherapy (P ＞ 0.05),but the levels of serum VEGF,CEA,CA19-9 and CA125 after chemotherapy were significantly lower than those before chemotherapy (P ＜0.05).There was no significant difference in serum HGB,VEGF,CEA,CA19-9 and CA125 levels among the three groups before chemotherapy (P ＞ 0.05).The levels of serum HGB,VEGF,CEA,CA19-9 and CA125 after chemotherapy were significantly lower than those before chemotherapy in the effective group (P ＜ 0.05).There was no significant difference in the levels of serum HGB,VEGF,CEA,CA19-9 and CA125 before and after chemotherapy in the stable disease group (P ＞ 0.05).There was no significant difference in the levels of serum HGB,VEGF,CEA and CA19-9 before and after chemotherapy in the progressive disease group (P ＞ 0.05);but the level of serum CA125 after chemotherapy was significantly higher than that before chemotherapy (P ＜ 0.05).The levels of serum HGB,VEGF,CEA,CA19-9 and CA125 in the effective group were significantly lower than those in the stable disease group and the progressive disease group after chemotherapy (P ＜ 0.05).There was no significant difference in serum HGB,VEGF and CA19-9 levels between the stable disease group and the progressive disease group (P ＞ 0.05);but the levels of serum CEA and CA125 in stable disease group were significantly lower than those in the progressive disease group after chemotherapy (P ＜ 0.05).Multiple regression analysis showed that the changes of the levels of serum CEA,CA19-9,CA125 and VEGF were significantly correlated with the effect of chemotherapy (P ＜ 0.05);the sequence of the correlation was CEA,CA19-9,CA125 and VEGF.There was no significant correlation between the serum HGB level and the effect of chemotherapy (P ＞0.05).Conclusion The changes of serum CEA,CA19-9,CA125 and VEGF levels were correlated with the effect of chemotherapy in patients with gastric cancer.Detecting serum CEA,CA19-9,CA125 and VEGF levels is helpful to predict the effect of chemotherapy.