Study on the pathogenesis of transient intraocular pressure after laser iridectomy with Krypton laser combined with Q -switched Nd:YAG laser / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
;
(12): 2222-2225, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-669411
ABSTRACT
·AIM:
To study the pathogenesis of transient intraocular pressure ( IOP ) after laser iridectomy with Krypton laser combined with Q-switched NdYAG laser.·METHODS:
Totally 42 healthy rabbits ( 84 eyes ) provided by the Animal Experimental Center of our hospital were selected, including 18 female rabbits, 24 male rabbits, average weight 2. 24±0. 31kg, and they were randomly divided into 6 groups, 7 rats in each group (14 eyes) . We observed the change of intraocular pressure after laser iridectomy surgery at 20min, 2, 6, 18, 24h and the nitric oxide ( NO ) , malondialdehyde ( MDA ) , superoxide dismutase ( SOD) , 6-keto-prostaglandin ( 6-keto-PGF1α) and nitric oxide synthase ( NOS) content in aqueous.·RESULTS:
There was no significant difference in intraocular pressure, NO, NOS, SOD, MAD and 6-keto-PGF1α before operation ( P > 0. 05 ). The intraocular pressure increased after operation, and the difference was statistically significant (P<0. 05) at 20min, 2 and 6h after operation, and decreased at 18h after operation, 24h after operation (P>0. 05). The levels of NO, NOS and SOD in the aqueous humor of the two groups decreased 20min, 2 and 6h after the operation (P<0. 05), while increased after 6h, increased more at 18 and 24h. The difference with control group was no more significant (P>0. 05). The levels of MDA and 6-keto-prostaglandin in the aqueous humor increased after the operation, and the difference was statistically significant at 20min, 2 and 6h after operation (P<0. 05), while decreased at 18 and 24h and the difference with control group was not significant ( P>0. 05).·CONCLUSION:
The increase of transient intraocular pressure after laser iridectomy may relate to the increase of malondialdehyde, 6-keto-prostaglandin content and the decrease of superoxide dismutase and nitric oxide in the aqueous humor after operation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
Language:
Chinese
Journal:
International Eye Science
Year:
2017
Type:
Article
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