Preparation and Dissolution of Jieheling Dispersible Tablets / 中国药师
China Pharmacist
;
(12): 517-519, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-669665
ABSTRACT
Objective:
To prepare Jieheling dispersible tablets and establish the dissolution determination method.Methods:
The dissolution of fischeriana B in the tablets was determined by HPLC. The column was Kromasil C18(250 mm ×4.6 mm,5μm)with ace-tonitrile-water (40∶60) as the mobile phase at a flow rate of 1. 0 ml·min-1 . The detection wavelength was at 290nm. The column temperature was 30℃ and the sample size was 100 μl.Results:
The linear range of fischeriana B was 0. 005-0. 057 μg ( r =0. 999 6). The average recovery was between 95% and 105%. Phosphate solution with pH of 6. 8 was used as the dissolution medi-um.Conclusion:
The method is simple, accurate and specific, and can be used in the quality control of Jieheling dispersible tablets.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2015
Type:
Article
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