Study of Simulation Application of Simulink Pharmacokinetic Compartment Model / 中国药师
China Pharmacist
;
(12): 736-740, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-669781
ABSTRACT
Objective:
To dynamically describe the drug concentration change in different time in vivo to understand the in vivo be-havior patterns and rules of drugs, provide reference for performing individual treatment and avoiding adverse drug reactions and lay foundation for dynamic description of physiological pharmacokinetic model.Methods:
A two-compartment model was established using Simulink dynamic simulation and used in curve fitting and parameter estimation. The results from the model were compared with those from 3P97 software.Results:
There was no significant difference between the results from the dynamic model and those from 3P97 soft-ware.Conclusion:
The dynamic model can be used to dynamically simulate two-compartment model for oral administration. The re-sults from the dynamic simulation are more direct, and can correct the fitting error in 3P97 software.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2015
Type:
Article
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