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Extraction Process Optimization of Total Flavonoids in Gynostemma Pentaphyllum by Response Surface A-nalysis / 中国药师
China Pharmacist ; (12): 714-717, 2015.
Article in Chinese | WPRIM | ID: wpr-669783
ABSTRACT

Objective:

To optimize the extraction process of total flavonoids in Gynostemma pentaphyllum by the method of response surface analysis ( RSM) .

Methods:

Based on the choice of factors and levels according to the results of single factor test, Box-Be-hnken response surface experiment was designed with the extraction rate of total flavonoids as the index to obtaln the best operation con-ditions and two equations of the response surface model.

Results:

The optimal extraction conditions of total flavonoids in Gynostemma pentaphyllum were as followsthe volume fraction of ethanol was 71%, the ratio of solid to liquid was 1∶14, and the ultrasonic time was 32 min. Under the conditions, the model predictive value of extraction rate of total flavonoids in Gynostemma pentaphyllum was 4. 676%, and the extraction rate in the verification test was 4. 641%.

Conclusion:

The fit of the regression model is good, and the ex-traction technology is feasible and reliable.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: China Pharmacist Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: China Pharmacist Year: 2015 Type: Article