An open label study of the effects of oral prednisone on neuromyelitis optica / 中国神经精神疾病杂志
Chinese Journal of Nervous and Mental Diseases
; (12): 145-149, 2015.
Article
in Zh
| WPRIM
| ID: wpr-669948
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WPRO
ABSTRACT
Objective To evaluate the efficacy and safety of oral prednisone in patients with relapsing neuromyeli?tis optica. Methods Seventeen patients with relapsing neuromyelitis optica receiving long-term oral prednisone had been followed. The Expanded Disability Status Scale (EDSS) and annualized relapse rates were used to evaluate curative effect. Results During long-term oral prednisone treatment, patients had a significant reduction in the EDSS [(3.09 ± 0.85) vs. (4.06 ± 0.80), P<0.05] and the median annualized relapse rate was significant reduced [(0.34 ± 0.31) vs. (1.51 ± 0.57), P<0.005]. But the effect of different dosage of prednisone on annualized relapse rates was not different. No severe adverse re?actions were observed. Conclusions Treatment with long-term oral prednisone in patients with NMO significantly reduces relapse rates, improves neurological function and the treatment was well-tolerated.
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WPRIM
Language:
Zh
Journal:
Chinese journal of nervous and mental diseases
Year:
2015
Type:
Article