Preparation of Pingwei Dispersible Tablets and Content Determination of Atractylodin / 中国药师
China Pharmacist
;
(12): 671-673, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-669961
ABSTRACT
Objective:
To prepare Pingwei dispersible tablets and establish a method for the determination of atractylodin. Meth-odsHPLC was performed on a Kromasil C18 column(250 mm × 4. 6 mm,5 μm)using methanol-water(7525)as the mobile phase at a flow rate of 1 ml·min-1 . The detection wavelength was at 340nm. The column temperature was 30℃ and the injection volume was 10 μl.Results:
The optimized formula of the tablets was as followsthe proportion of inner disintegrant microcrystalline cellulose,out-side disintegrant carboxymethyl cellulose sodium and HPMC was 40%,9% and 2%,respectively. The adhesive was 2% HPMC in 70% ethanol,and 1. 5% magnesium stearate was used as the lubricant. The linear range of atractylodin was 0. 100 6-0. 503 0 μg(r=0. 999 9),and the average recovery was 99. 3%(RSD=0. 9%,n=6).Conclusion:
The formula and the preparation process of the tablets are reasonable and the content determination method is simple,accurate and specific,which can be used in the quality control of Pingwei dispersible tablets.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2015
Type:
Article
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