Effect of Traditional Chinese Medicine Practolol Oral Liquid on Water Load Rat Model / 中国药师
China Pharmacist
;
(12): 1810-1813, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-670054
ABSTRACT
Objective:
To investigate the influence of practolol oral liquid on the rat model of water load.Methods:
Totally 70 qualified rats were selected and randomly divided into seven groups with 10 ones in each, and the rats were with intragastric administra-tion respectively by practolol oral liquid (20,10 and 5 ml·kg-1 , respectively diluted 20 ml, 10 ml and 5 ml to 20 ml liquid with dis-tilled water), furosemide tablets suspension (0. 033 5 mg·ml-1), Qiliqiangxin capsule suspension(0. 03 g·ml-1) and distilled wa-ter with the same voulme( model) . The rats were placed in metabolism cages. After the administration, the urine volume was recorded every 1 h for 5 hours, the total volume of urine was collected during the 5 h, and the concentration of Na+, K+ and Cl- in the urine was measured.Results:
Compared with that in the blank group, the urine volume in 2 h, 3 h and 5 h after the administration in the model group was significantly increased(P0. 05), high-dose practolol oral liquid could significantly increase the Na+ concentration in the urine (P0. 05), however, the total urine volume could significantly increase(P<0. 01), and the medium and low-dose practolol oral liquid could significantly reduce the Na+ and Cl- con-centration in the urine(P<0. 01).Conclusion:
Practolol oral liquid has significant diuretic effect in a dose-dependent manner.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2015
Type:
Article
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