Observation of Mifepristone Combined with Ethaeridine in Inducing Labor at Second Trimester of Preg-nant Women with Scarred Uterus / 中国药师

ABSTRACT

Objective:To observe the clinical effects and safety of mifepristone combined with ethaeridine in inducing labor at sec-ond trimester of pregnant women with scarred uterus. Methods:Totally 84 cases were randomly divided into the control group and the study group with 42 ones in each. The control group received intrauterine injection of ethaeridine for inducing labor, and the study group received mifepristone additionally for inducing labor. The time intervals from administration to uterine contraction and from induc-tion to delivery, auxiliary medication rate, fetal weight, volume of postpartum hemorrhage, successful rate of induction, adverse events of induction and adverse drug reactions were compared. Results:Compared with those in the control group, the time intervals from ad-ministration to uterine contraction and from induction to delivery were shorter in the study group, and the clear uterine rate and total ad-verse event rate of induction were lower in the study group(P<0. 05). Conclusion: Mifepristone combined with ethaeridine is safer and more effective than ethaeridine alone, which is an appropriate alternative for inducing labor at second trimester of pregnant women with scarred uterus.