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Association of rs1013940 polymorphism in SLC5A7 with Tourette syndrome in Chinese Han popula-tion / 中华行为医学与脑科学杂志
Article in Zh | WPRIM | ID: wpr-670235
Responsible library: WPRO
ABSTRACT
Objective To investigate the association between rs1013940 in SLC5A7 and Tourette Syndrome ( TS) in Chinese Han population.Methods Polymorphism was genotyped in 401 TS nuclear fam-ilies trios from china by real-time fluorescent quantitive PCR.Transmission disequilibrium test ( TDT) and Haplotype relative risk ( HRR ) were used to analyze the association between the genetic distrbution of rs1013940 and TS and the results were verified by haplotype-based haplotype relative risk( HHRR) .Results No transmission disequilibrium was found between rs1013940 in SLC5A7 and TS by TDT and HRR( TDT:χ2=0.268, P=0.657, OR=0.728,95%CI=0.366-1.451;HRR:χ2=0.111, P=0.739, OR=0.959,95%CI=0.762-1.466) .HHRR also indicated the same result ( HHRR:χ2=0.276, P=0.599, OR=1.082,95%CI=0.806-1.453) .Conclusion The result reveals that there is no significant association between rs1013940 in SLC5A7 and TS in Chinese Han population.However,the results need to be further validated in different populations.
Key words
Full text: 1 Index: WPRIM Type of study: Etiology_studies Language: Zh Journal: Chinese Journal of Behavioral Medicine and Brain Science Year: 2016 Type: Article
Full text: 1 Index: WPRIM Type of study: Etiology_studies Language: Zh Journal: Chinese Journal of Behavioral Medicine and Brain Science Year: 2016 Type: Article