The expression of Th1/Th2 type cytokines and clinical significance in Uyghur cervical cancer / 实用肿瘤学杂志

ABSTRACT

Objective To assess the immune level of cervical cancer patients and precancerous lesions patients,and investigate the association of Th 1 /Th2 type cytokines expression and clinical pathologic factors in the plasma of Uyghur cervical cancer patients .Methods we collected peripheral blood specimens from cervical cancer patients,precancerous lesion(CINⅢ)patients and controls.The expressions of Th1 type cytokines IL-2, IFN-γand Th2 type cytokines IL-4,IL-10 in plasma were detected by ELISA .Receiver operating characteris-tic curve( ROC curve) was used to analyze the cytokines value of auxiliary diagnosis in cervical cancer .Results The results showed that compared with control group ,the expressions of Th1 type cytokines IL-2,IFN-γin cer-vical cancer and precancerous lesion group were significantly reduced (P<0.05).The expressions of Th2 type cytokines IL -4, IL -10 in cervical cancer and precancerous lesion group were significantly increased ( P <0.05).in cervical cancer group,IL -10 expression gradually increased with tumor pathological staging (P <0.05).IL-2 expression level in Uyghur cervical cancer patients was significantly lower than in Han patients (P<0.05).Compared cervical cancer group with control group ,AUC of IL-2,IFN-γ,IL-4 and IL-10 were 0.979,0.766,0.736 and 0.903.Conclusion Cellular immune level of cervical cancer patients was low and Th1/Th2 shift has occurred , which suggests that it may be one of the mechanisms in immune escape of tumor cells.Th1 /Th2 type cytokines detection has a certain significance for auxiliary diagnosis of cervical cancer .Be-sides,the decrease of IL-2 expression may play an important role in the occurrence and development of Uyghur patients with cervical cancer .