Effect of recombinant human basic fibroblast growth factor on cell proliferation during mandible fracture healing in rabbit / 实用口腔医学杂志
Journal of Practical Stomatology
;
(6)2000.
Article
in Chinese
| WPRIM
| ID: wpr-670506
ABSTRACT
objective:
To investigate the effect of recombinant human basic fibroblast growth factor (rhbFGF) on cell proliferation during mandible fracture healing. Methods 8 ?g of rhbFGF in 0.3 ml of H 2O was mixed with 1.6 ml of bovine type 1 collagen and then the mixture was vacuumed to be a membrane. The membrane was implanted around the mandibular fracture following the fracture was made in 25 rabbits. 5 animals were sacrificed 1,2,4,8 and 12 weeks respectively after operation. Proliferating cell nuclear antigen (PCNA) in callus was examined with immunohistochemical staining. Type 1 collagen membrane was used as the control in another 25 rabbits.Results:
1 week after operation, PCNA positive cell(%) in callus in rhbFGF treated and control group were 65.2?6.1 and 32.0?5.5 respectively ( P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Practical Stomatology
Year:
2000
Type:
Article
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