Effects of doxycycline on the proliferation and invasion of adenoid cystic carcinoma SAcc83 cells / 实用口腔医学杂志
Journal of Practical Stomatology
;
(6)2000.
Article
in Chinese
| WPRIM
| ID: wpr-670524
ABSTRACT
Objective:
To study the effects of doxycycline on the proliferation and invasion of adenoid cystic carcinoma cells.Methods:
MTT assay was applied to study the effects of doxycycline on proliferation of SAcc83 cells. Activity of type IV collagenase was detected by the method of gelatin incorporated SDS PAGE electrophoresis.Monolayer cell organ culture was carried out to study the invasion of the cells.Results:
Doxycycline at 5~50 ?g/ml inhibited the proliferation of adenoid cystic carcinoma cell in a dose and time dependant manner. 10 ?g/ml of the drug inhibited type Ⅳ collagenase and decreased the invasion of adenoid cystic carcinoma cells by 48%.Conclusion:
Doxycycline can inhibit proliferation and invasion of SAcc83 cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Practical Stomatology
Year:
2000
Type:
Article
Similar
MEDLINE
...
LILACS
LIS