Inhibitory effects of homoharringtonine and/or methoxsalen on highly metastatic human mucoepidermoid carcinoma Mc3 cells / 实用口腔医学杂志

ABSTRACT

Objctive To study the inhibitory effects of homoharringtonine(HHT) or methoxsalen (8-MOP) or in combinnation on humen highly metastatic mucoepidermoid carcinoma Mc3 cells. Methods: Mc3 cells were exposed to the drugs or their combination at various concentrations. The inhibitory effects were tested with MTT assay. Results: The IC 50 values of HHT and 8-MOP were 79.43 ng/ml and 5 980 ng/ml respectively, HHT at the doses of 1-320 ng/ml combined with 8-MOP at 800, 4 000 and 20 000 ng/ml the CI 50 values were 0.76?0.33 and 0.15 respectively.Conclution The data indicate that combination of HHT with 8-MOP is synergic in the inhibition of Mc3 cell growth.