Effects of estrogen on the structure of mandible and femur in ovariectomized rats / 实用口腔医学杂志

ABSTRACT

Objective: To investigate the effects of estrogen (E 2) on the structure of madible and femur in ovariectomized rats. Methods: 18 femal SD rats were evenly divided into 3 groupssham-ovariectomized rats (sham-OVX),ovariectonmized rats without E 2 treatment (osteoporosis,OP) and ovariectomized rats with E 2 treatment (E 2).In the group of E 2,E 2 at the dose of 10 ?g/kg was injected into abdominal cavity of the rats every the other 2 days.All rats were sacrificed after 6-week treatment.The madible and femur samples were analyzed by bone histomorphometry with QWin550CW system. Trabecular area (Tb.Ar,%), trabecular width (Tb.Wi,?m) and trabecular seperation (Tb.Sp,?m) were calculated.Result: Tb.Ar(%),Tb.Wi (?m) and Tb.Sp(?m) in the madibles in sham-OVX rats were 29.43?3.12,10.97?1.85 and 27.59?4.21;in OP 19.44?2.24,6.45?1.73 and 42.03?5.46;in E 2 treated 26.81?2.93,9.54?1.22 and 30.98?3.65,respectively.Those in the femus in sham-OVX rats were 24.19?5.53,56.72?10.36 and 132.41?47.69;in OP 12.54?4.32,40.71?8.65 and 208.67?65.39;in E 2 treated 20.08?4.86,51.38?9.07 and 159.42?56.34,respectively.Conclusion: The bone volume decreases more in femur than in madible after ovariectomy in rats.Treament of estrogen can inhibit bone absorbtion in mandible and femur.