Effects of dexamethasone on TGF-?_1 and TGF-?_2 expression during the induction of cleft palate in mice / 实用口腔医学杂志
Journal of Practical Stomatology
;
(6)2000.
Article
in Chinese
| WPRIM
| ID: wpr-670648
ABSTRACT
Objective:
To investigate the effects of TGF-? 1 and TGF-? 2 on cleft palate formation .Methods:
30 pregnant NIH mice in experimental group were injected with dexamethasone (50 mg/kg) intr aperitoneally in GD 12 12 ,30 mice in control group were given the same vo lume of NS.Fetuses were removed out in GD13 12 ,GD14 12 and GD15 12 , heads of the mice were sliced in coronal plane.Expression of TGF-? 1 an d TGF-? 2 in embryonic palate were detected by immunohistochemicalmethods:
Results:
Dexamethasone (50 mg/kg) induced cleft palate in NI H embryos,and expression of TGF-? 1 and TGF-? 2 in palate tissues was h igher in the experimental group than that in the control (P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Practical Stomatology
Year:
2000
Type:
Article
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