Inhibitory effects of green-tea polyphenol on inflammatory agents in gingival epithelial cells / 实用口腔医学杂志
Journal of Practical Stomatology
;
(6)1995.
Article
in Chinese
| WPRIM
| ID: wpr-670906
ABSTRACT
Objective:
To study the effects of green-tea polyphenol, (epigallocatechin gallate,EGCg) on the cellular inflammatory responses of gingival epithelial cells. In order to find out a safe and efficient inflammation-inhibitor for periodontitis prevention and treatment.Methods:
A model of cellular inflammatory responses of gingival epithelial cells stimulated by Porphyromonas gingivalis vesicles in vitro was established. The effects of EGCg on PGE2 production of gingival epithelial cells was detected by ELISA. Further more, the effects of EGCg on COX (cyclooxygenase)-2 and MMP (matrix metalloproteinase)-3 mRNA expression were determined by Real-time RT-PCR.Results:
EGCg dose-dependently inhibited PGE2 production and COX-2, MMP-3 mRNA expressions.Conclusion:
EGCg has inhibitory effects on cellular inflammatory responses of gingival epithelial cells and possesses the potentiality to be a periodontal inflammation-inhibitor.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Practical Stomatology
Year:
1995
Type:
Article
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