Effect of Bifid Triple Viable Capsules on Plasma D-Lactic Acid and Stool S-IgA in Patients with Colorectal Cancer after Operation / 中国药师

ABSTRACT

Objective:To discuss the effect of bifid triple viable capsules on plasma D-lactic acid and stool S-IgA in the patients with colorectal cancer after the operation. Methods:Totally 68 cases of patients with colorectal cancer after the operation were selected and divided into the observation group and the control group at random. The patients in the two groups were given enteral nutrition and postoperative routine medical treatment with the treatment course of one week from the third day after the operation. The patients in the observation group were additionally given 620 mg bifid triple viable capsules, twice a day. The occurrence rates of diarrhea and flora imbalance, D-lactic acid in plasma, S-IgA in stool and adverse drug reaction ( ADR) in the two groups were observed and compared after the medical treatment. Results:After the one-week medical treatment, the occurrence rates of diarrhea and flora imbalance in the observation group were much lower than those in the control group (P<0. 05). After the treatment, D-lactic acid in plasma in the two groups was declined, while S-IgA in stool was decreased than that before the treatment, and the changes in the observation group were more notable than those in the control group (P<0. 05 or P<0. 01). No obvious ADR appeared in the two groups during the medical treatment. Conclusion:The application of bifid triple viable capsules in the patients with colorectal cancer after the operation can re-duce D-lactic acid in plasma and ralse S-IgA in stool, which can effectively recover intestinal mucosal barrier function and local immu-nity, and reduce alteration of intestinal flora and occurrence of diarrhea with high security.