Preparation and in vitro Release of Metoclopramide Orally Disintegrating Tablets / 中国药师
China Pharmacist
;
(12): 1882-1884,1894, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-671172
ABSTRACT
Objective:
To prepare and optimize the formula of metoclopramide orally disintegrating tablets, and investigate the in vitro drug dissolution behavior.Methods:
The formula was optimized by full-factorial experiment design, the ratio of mannotil to micro-crystalline cellulose ( X1 ) and the amount of disintegrating agent ( X2 ,%) were selected as the independent variables, and the friabili-ty ( Y1 ,%) , disintegration time ( Y2 , s) and metoclopramide dissolution ( Y3 ,%) were used as the dependent variables. The release rate of metoclopramide orally disintegrating tablets in different dissolution media was studied.Results:
The optimum formula of meto-clopramide orally disintegrating tablets was as followsthe ratio of mannotil to microcrystalline cellulose was 2. 5∶ 1, and the amount of disintegrating agent was 6. 5%. The dissolution of metoclopramide orally disintegrating tablets in the different dissolution media was o-ver 80%.Conclusion:
The formula design is reasonable, the preparation process is feasible and the quality can be controlled.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2015
Type:
Article
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