Mechanisms of HIV envelope-induced T lymphocyte apoptosis / 中国病毒学·英文版
Virologica Sinica
; (6): 307-315, 2010.
Article
in Zh
| WPRIM
| ID: wpr-671396
Responsible library:
WPRO
ABSTRACT
Infection by the human immunodeficiency virus (HIV) is characterized by a progressive depletion of CD4 T lymphocytes, which leads to dysfunction of the immune system. Although a variety of mechanisms may contribute to the gradual T cell decline that occurs in HIV-infected patients, abnormal apoptosis of infected or bystander T lymphocytes is an important event leading to immunodeficiency. The HIV envelope glycoprotein plays a crucial role in HIV associated apoptosis through both death receptor-mediated and mitochondria-dependent pathways. This review summarizes current knowledge of Env-mediated T lymphocyte apoptosis.
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Language:
Zh
Journal:
Virologica Sinica
Year:
2010
Type:
Article