Identification and biological characteristic of melatonin receptor in human embr yonic nervous system / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 12-14, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-671522
ABSTRACT
Objective:
To verify whether there exists melatoni n(Mel) receptor in human embryonic nervous system.Methods:
Spec ific binding of Mel to embryonic brain and spinal cord was measured by radioliga nd binding assay.Results:
125 I-Mel binding s ites in optomeninx was the most, in eptochiasm and sniff ball was next; GTPγS d ose-de pendently inhibited the binding.Conclusion:
The results demonst rate the presence of specific binding of Mel in human embryonic brain and spinal cord. GTPγS has some effect on 125 I-Mel specific binding,support ing the theory that Mel receptor is coupled to inhibitory G-proteins.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
/
Prognostic study
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2001
Type:
Article
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