Impact of the signal path PD-1/PD-L1 on Treg cells and tumor cells / 国际肿瘤学杂志
Journal of International Oncology
; (12): 808-810, 2014.
Article
in Zh
| WPRIM
| ID: wpr-671981
Responsible library:
WPRO
ABSTRACT
Programmed death-1 (PD-1) and its ligand PD-L1 are the major members of inhibitory costimulatory molecules and express high in a variety of tumor cells and their associated cells surface,while the proportion of regulatory T cells (Tregs) are abnormally elevated in tumor infiltrating T lymphocytes cells.PD-L1 combined with PD-1 and Treg help tumors evade immune clearance,weaken immune responses and induce immune tolerance.New researches find that PD-L1 plays an important role in the development and function maintenance of inducible Treg (iTreg),and PD-L1 signal can change initial CD4 + CD25-T cells into iTreg to play a role of immunosuppression.Research on PD-1 signaling pathway can provide a new theoretical basis for the inhibition of tumor immune escape in clinical application of immunotherapy and better treatments.
Full text:
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Index:
WPRIM
Language:
Zh
Journal:
Journal of International Oncology
Year:
2014
Type:
Article