Association between genetic polymorphism in DNA repair genes XRCC3 and risks of laryngeal carcinoma / 中国耳鼻咽喉头颈外科
Chinese Archives of Otolaryngology-Head and Neck Surgery
;
(12): 511-514, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-672942
ABSTRACT
OBJECTIVE To study the association between polymorphism of DNA repair gene XRCC3Thr 241 Met and the risks of developing laryngeal carcinoma. METHODS Sixty patients with laryngeal carcinoma and 120 cancer-free controls were genotyped for the polymorphism by Multiplex SNaPshot.The odds ratios (ORs) and 95% confidence intervals (Cls) were calculated using unconditional logistic regression model.RESULTS The XRCC3 241 Met allele increased the risks of developing laryngeal carcinoma.Comparing with subjects having the XRCC3241 Thr/Thr genotype,the subjects at least having one XRCC3 241 Met allele had OR of 4.27 (95%CI 1.49-12.18). CONCLUSION XRCC3 Thr 241 Met plays an important role in the development of laryngeal carcinoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
Language:
Chinese
Journal:
Chinese Archives of Otolaryngology-Head and Neck Surgery
Year:
2016
Type:
Article
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