STUDIES ON RP-HPLC FOR THE SIMULTANEOUS DETERMINATIONS OF CHLORPROMAZINE AND CLOZAPINE IN HUMAN SERUM AND CLINICAL APPLICATIONS / 中国法医学杂志
Chinese Journal of Forensic Medicine
;
(6)1986.
Article
in Chinese
| WPRIM
| ID: wpr-673129
ABSTRACT
1ug/ml),chromatographing ona 300?3.9mm 1.D.colomn packcd with u Bondapak C_(18)(10um),and detecting at UV254nm.The mobile phase was MeOH-H_2O-TEMED-HAC(65350.30.52)The average recovery of the whole procedure were 99.9?4.1(SD)%.CV=4.1%for clozapine)98.5?4.0(SD)%,CV=4.2% for chlopromazine.The Minimum detetionlimit was 10ng/ml serum.The developed method was applied to clinical monitoring of serum levels from11 patients who wereco administered with multiple oral doses of clozapine and chlor-promazine.The serum concentrations of 0.150-0.445?g/ml and 0.014-0.086?g/ml werefound.Futhermore,one case of suicide was encountered.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Forensic Medicine
Year:
1986
Type:
Article
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