Study on the effect of monosodium glutamate on the body temperature and its mechanism in rabbit / 中国病理生理杂志

ABSTRACT

With 58 of New Zeeland rabbits, following experiments were carried out (1) the dose-response relationship of MSG which decreased the body temperat ure; (2) the effects of the propranolol and the anisodamine (654-2) on the action of decreasing body temperature by MSG. The results indicated following intravenous administration of MSG at a dose of 0.5g/kg. w and 1.0g/kg. w, the body temperature of rabbits were decreased significantly, but at a dose of 0.1g/kg.w, the change of temperature was insignificant.Pretreatment with propranolol did not affect the effect of MSG decreasing body temperature which was blocked significantly by anisodamine, one of blocker of the cholinergic nerve. The authors suggest that the effect of MSG decreasing body temperature may depend on the cholinergic nerve.