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The effect of propofol on pulmonary artery pressure and hypoxic pulmonary vasoconstriction reaction in rat / 中华麻醉学杂志
Article in Chinese | WPRIM | ID: wpr-673349
Responsible library: WPRO
ABSTRACT

Objective:

To investigate the effect of dosages of propofol on pulmonary artery pressure (PAP) and hypoxic pulmonary vasoconstriction(HPV) reaction.

Method:

Isolated rat lungs were perfused with whole blood at the rate of flow 10ml/min and ventilated with air+4%CO_2(n=5) or 3% O_2+4%CO_2+93% N_2(mixed gas, n=11).PAP was measured continuously during the whole procedure.

Result:

PAP decreased significantly in air+4% CO_2 ventilation following administralion of propofol 4 mg/kg,6 mg/kg and 8 mg/kg respectively.The varied degrees at 6 mg/kg and 8mg/kg were even more marked than that at 4mg/kg. When mixed gas was ventilated into lung, PAP increased from 1.60+0.23kPa to 2.384?0.31kPa to produce HPV,PAP decreased abruptly in HPV rats when administered 4mg/kg, 6mg/kg and 8mmg/kg propofol respectively and HPV reaction was inhibited by 47%, 867%and 71% respectively,the inhibition extent was more at 6mg/kg or 8mg/kg than that at 4mg/kg.

Conclusion:

Propofol can decrease PAP and inhibite HPV in dose-dependent way.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Anesthesiology Year: 1997 Type: Article
Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Anesthesiology Year: 1997 Type: Article