Graves' disease and endocrine ophthalmopathy / 中国普通外科杂志

ABSTRACT

Objective To summarize the pathogenesis and diagnosis experience of the ophthalmopathy in Graves' disease. Methods The summarize paper made on eviewing correlative documents. Results ①The endocrine ophthalopathy occupies about 25 percent in the Graves' disease patient. The clinical manifestation is infiltrating exophthalmic tissues, bulbar conjunctiva edema, ophthalmus muscles spasm and anopsia. ②It is a special auto immune disease. Thyrotrophin receptor antibody(TRAb) infiltrates the thyroid gland and internal orbital tissues to cause lymph cells infiltration and inflammatory reaction that can change the visual organ structure. The internal orbital IgA content also rise. ③Antithyroid drug, hormones and postorbital irradiation can be used to treat this disease, but total thyroidectomy can decrease the TRAb concentration in blood which has prominent therapeutic effect. Conclusions Graves disease is an auto immune disease, foe treatment of endocrine ophthalmopathy, total tyroidectomy is necessary as early as possible.