Gene therapy for restenosis of the vessel / 中国普通外科杂志

ABSTRACT

Objective To understand the experimentnl resluts and the advance in gene therapy for restenosis of the vessel. Method Literature review was made on gene therapy for restenosis directly at cytotoxic, cell cycle regulators, intracellular signal transducers, transcription factors, cytokines growth factors, nitric oxide and Fas ligand. Results cytotoxic gene therapy by thymidine kinase and cytosine deaminase, mutant retinoblastoma protein (Rb), cyclin-dependent kinases(cdk) inhibitors (such as p21 p27 and p53), antisense basic fibroblast growth factor (bFGF) blocking intracellular signal transduce by A-Raf and C-Raf, antisense Ag ??, promoting NO, ?-nterferon, vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF), ? chain synthesize suppressing nuclear factor-kB (NF-kB) overexpression of gax and Fas ligand can inhibit restenosis of the vessel. Conclusions The effect of gene therapy for restenosis of the vessed is obvious in experimental studies. Conbination of more gene and several links gene therapy is the research direction in the future.