A Voxel Wise Analysis of Cerebral Beta Amyloid Retention in Healthy Controls and Subjects with Amnestic Mild Cognitive Impairment and Alzheimer's Disease
Journal of Korean Geriatric Psychiatry
;
: 75-79, 2016.
Article
in Korean
| WPRIM
| ID: wpr-67358
ABSTRACT
OBJECTIVE:
The purpose of the study was to compare cortical amyloid deposition using 18F-florbetaben and positron emission tomography (PET) in healthy controls and subjects with amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD).METHODS:
We investigated 25 patients 10 age-matched healthy controls, 10 patients with aMCI and 5 with AD. All participants underwent PET after intravenous injection of 300 MBq of 18F-florbetaben. The 90 min post-injection brain PET data were analysed using statistical parametric mapping.RESULTS:
When compared to healthy controls, amyloid deposition was significantly higher in frontal lobe medial frontal gyrus, limbic lobe posterior cingulate, parietal lobe precuneus, sub-loba insula, temporal lobe superior temporal gyrus, parietal lobe inferior parietal lobule, temporal lobe middle temporal gyrus, parietal lobe supramarginal gyrus, occipital lobe middle temporal gyrus of patient group (family wise error correction p<0.05).CONCLUSION:
These results indicate 18F-florbetaben to be an efficacious β-amyloid-targeted tracer. Subjects with aMCI, AD could be easily differentiated from healthy controls by assessment of the PET data.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parietal Lobe
/
Temporal Lobe
/
Brain
/
Prefrontal Cortex
/
Plaque, Amyloid
/
Positron-Emission Tomography
/
Alzheimer Disease
/
Cognitive Dysfunction
/
Limbic Lobe
/
Frontal Lobe
Limits:
Humans
Language:
Korean
Journal:
Journal of Korean Geriatric Psychiatry
Year:
2016
Type:
Article
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