Your browser doesn't support javascript.
loading
Expression of Desmoglein 1 and 2 in Different Epidermal Tumors / 中华皮肤科杂志
Article in Zh | WPRIM | ID: wpr-673602
Responsible library: WPRO
ABSTRACT
Objective To evaluate the relationship between desmosome-related proteins and epidermal tumors. Methods Using anti-desmoglein 1 and 2 monoclonal antibodies, expression of desmoglein 1 and 2 was examined by an immunohistochem ical staining method in various epidermal tumors such as squamous cell carcinoma (SCC), actinic keratosis(AK), keratoacanthoma(KA) and seborrhoeic keratosis(SK). Results Desmoglein 1 and 2 were strongly expressed in intercellular space of wh ole epidermis in normal human skin. Expression of desmoglein 1 and 2 was markedl y reduced or absent in SCC cells. Compared with normal epidermal cells, expressi on of desmoglein 1 and 2 was equal to or reduced,with complete absence of stain ing in dysplastic areas in AK cells. Extensive pericellur staining of desmoglein 1 and 2 was found in KA and SK cells, similar to that observed in normal epider mis. Conclusion Expression of desmoglein 1 and 2 is markedly reduced or absent i n human malignant epidermal cancers, reduction of these molecules may contribute to invasiveness and metastasis of epidermal carcinomas.
Key words
Full text: 1 Index: WPRIM Language: Zh Journal: Chinese journal of dermatology Year: 1994 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Chinese journal of dermatology Year: 1994 Type: Article