Immunohistochemical study of endothelin in early acute myocardial ischemia in rats / 中国法医学杂志
Chinese Journal of Forensic Medicine
;
(6)1988.
Article
in Chinese
| WPRIM
| ID: wpr-673765
ABSTRACT
Objective Study the expression of endothelin(ET) of ischaemic myocardium in rat. Method Sixty Wistar rats were randomly divided into 5 groups coronary artery simply-ligated group,drug-pre-treated group(Isoproterenol,Pituitrin),coronary atherosclerotic group,sham-operated group(as control group). The samples were cut at 15min,30min,45min,60min,90min,120min after coronary (left anterior descending) ligation, and stained with HE and strept avidin-biotin enzyme complex(SABC)method. Results The expression of endothelin was observed with light microscope. Ischaemic myocardium showed ET-positive staining at the early stage of acute myocardial ischaemia in different groups and more in the pre-treated group. Conclusion the SABC-ET method may provide a new marker for diagnosing early myocardial ischaemia, which will be helpful in confirming the cause of sudden coronary death(SCD).
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Forensic Medicine
Year:
1988
Type:
Article
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