Analysis of diazepam and its main metabolites in urine by GC-ECD / 中国法医学杂志
Chinese Journal of Forensic Medicine
;
(6)2002.
Article
in Chinese
| WPRIM
| ID: wpr-673778
ABSTRACT
Objective A method was developed for the determination diazepam and its main metabolites,nordiazepam, and oxazepam and then in urine by GC-ECD. Method The urine samples were hydrolyzed with ?-glucuronidase were extracted in organic solvent. The extractives were derived with BSTFA and the analytes as trimethylsilyl derivatives were determined by GC. Results Sensitive of the method is as low as snglme, the recovery is high then 70%. Conclusion This method is sensitive enough for the analysis of urine from the subjects over a 48 hour period after receiving a 10mg dose of diazepam orally.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Forensic Medicine
Year:
2002
Type:
Article
Similar
MEDLINE
...
LILACS
LIS