Diagnostic value of cytokine levels in lung lavage fluid from preterm infants with chronic lung disease / 中华围产医学杂志

ABSTRACT

Objective To investigate the diagnostic value of dynamic level of TNF ?、IL 8、IL 1? and IL 6 in lung lavage fluid obtained from preterm infants with chronic lung disease (CLD). Methods Lung lavage were serially collected from 29 ventilated infants hospitalized in NICU from December 1999 to November 2002. Total cell counts, neutrophilic granulocyte counts, malondialdehyde, protein, TNF ?、IL 8、IL 1? and IL 6 in lung lavage fluid were examined. Among the 29 cases, 10 developed pneumonia, 6 HMD, 7 CLD and 6 without lung disease as control. Results Total cell counts(7.9?10 9/L), neutrophilic granulocyte counts(6.4?10 9/L), TNF ?(13.88 pmol/L)、IL 8(376.92 mg/L)、IL 1?(2.96 ?g/L)and IL 6(1.72 ?g/L) in lung lavage fluid in infants who developed CLD were higher than the others on day 5( P